CATH Domain 5tr0B05

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.245	Lipoxygenase-1; domain 5
	1.20.245.10	Lipoxygenase-1; Domain 5

Domain Context

CATH Clusters

Superfamily	Lipoxygenase-1; Domain 5
Functional Family	Lipoxygenase

Enzyme Information

1.13.11.12

Linoleate 13S-lipoxygenase.

based on mapping to UniProt P08170

(1) Linoleate + O(2) = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate. (2) Alpha-linolenate + O(2) = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca- 9,11,15-trienoate.

-!- A common plant lipoxygenase that oxidizes linoleate and alpha- linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C(13) position with (S)- configuration. -!- This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid. -!- EC 1.13.11.58 catalyzes a similar reaction at the second available position of these fatty acids. -!- Formerly EC 1.13.1.13 and EC 1.99.2.1.

UniProtKB Entries (1)

P08170

LOX1_SOYBN

Glycine max

Seed linoleate 13S-lipoxygenase-1

PDB Structure

PDB	5TR0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network. Hu, S., Offenbacher, A.R., Thompson, E.M., Gee, C.L., Wilcoxen, J., Carr, C.A.M., Prigozhin, D.M., Yang, V., Alber, T., Britt, R.D., Fraser, J.S., Klinman, J.P. J.Am.Chem.Soc.