CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.60 | Sandwich | |
2.60.60 | Lipoxygenase-1 | |
2.60.60.20 | PLAT/LH2 domain |
Domain Context
CATH Clusters
Superfamily | PLAT/LH2 domain |
Functional Family |
Enzyme Information
1.13.11.12 |
Linoleate 13S-lipoxygenase.
based on mapping to UniProt P08170
(1) Linoleate + O(2) = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate. (2) Alpha-linolenate + O(2) = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca- 9,11,15-trienoate.
-!- A common plant lipoxygenase that oxidizes linoleate and alpha- linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C(13) position with (S)- configuration. -!- This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid. -!- EC 1.13.11.58 catalyzes a similar reaction at the second available position of these fatty acids. -!- Formerly EC 1.13.1.13 and EC 1.99.2.1.
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UniProtKB Entries (1)
P08170 |
LOX1_SOYBN
Glycine max
Seed linoleate 13S-lipoxygenase-1
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PDB Structure
PDB | 5TQO |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network.
J.Am.Chem.Soc.
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