CATH Domain 5t8iA04

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1010	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
	3.30.1010.10	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4

Superfamily	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
Functional Family	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta

2.7.1.153

Phosphatidylinositol-4,5-bisphosphate 3-kinase.

based on mapping to UniProt O35904

ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.

-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.

PK3CD_MOUSE

Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

PDB	5T8I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Discovery of GS-9901: A Potent, Selective and Metabolically Stable Inhibitor of PI3Kd Patel, L., Chandrasekhar, J., Evarts, J., Forseth, K., Haran, A., Ip, C., Kashishian, A., Kim, M., Koditek, D., Koppenol, S., Lad, L., Lepist, E.-I., McGrath, M.E., Perreault, S., Puri, K., Villasenor, A., Somoza, J.R., Steiner, B., Therrien, J., Trilberg, J., Phillips, G. To Be Published