1 keywords

CATH Domain 5t8iA04

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1010 Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
Homologous Superfamily 3.30.1010.10 Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
Functional Family Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta

Enzyme Information

2.7.1.153
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt O35904
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.

UniProtKB Entries (1)

O35904
PK3CD_MOUSE
Mus musculus
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

PDB Structure

PDB 5T8I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Discovery of GS-9901: A Potent, Selective and Metabolically Stable Inhibitor of PI3Kd
Patel, L., Chandrasekhar, J., Evarts, J., Forseth, K., Haran, A., Ip, C., Kashishian, A., Kim, M., Koditek, D., Koppenol, S., Lad, L., Lepist, E.-I., McGrath, M.E., Perreault, S., Puri, K., Villasenor, A., Somoza, J.R., Steiner, B., Therrien, J., Trilberg, J., Phillips, G.
To Be Published