CATH Domain 5syhA04

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.420	Peroxidase; domain 2
	1.10.420.10	Peroxidase, domain 2

Domain Context

CATH Clusters

Superfamily	Peroxidase, domain 2
Functional Family	Catalase-peroxidase

Enzyme Information

1.11.1.21

Catalase peroxidase.

based on mapping to UniProt Q3JNW6

(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.

-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.

UniProtKB Entries (1)

Q3JNW6

KATG_BURP1

Burkholderia pseudomallei 1710b

Catalase-peroxidase

PDB Structure

PDB	5SYH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	An ionizable active-site tryptophan imparts catalase activity to a peroxidase core. Loewen, P.C., Carpena, X., Vidossich, P., Fita, I., Rovira, C. J. Am. Chem. Soc.