CATH Domain 5ox5A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.620	q2cbj1_9rhob like domain

Domain Context

CATH Clusters

Superfamily	q2cbj1_9rhob like domain
Functional Family	Egl nine homolog 1

Enzyme Information

1.14.11.29

Hypoxia-inducible factor-proline dioxygenase.

based on mapping to UniProt Q9GZT9

Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O(2) = hypoxia- inducible factor-trans-4-hydroxy-L-proline + succinate + CO(2).

-!- Contains iron, and requires ascorbate. -!- Specifically hydroxylates a proline residue in HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction. -!- The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.

UniProtKB Entries (1)

Q9GZT9

EGLN1_HUMAN

Homo sapiens

Egl nine homolog 1

PDB Structure

PDB	5OX5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Yeh, T.L., Leissing, T.M., Abboud, M.I., Thinnes, C.C., Atasoylu, O., Holt-Martyn, J.P., Zhang, D., Tumber, A., Lippl, K., Lohans, C.T., Leung, I.K.H., Morcrette, H., Clifton, I.J., Claridge, T.D.W., Kawamura, A., Flashman, E., Lu, X., Ratcliffe, P.J., Chowdhury, R., Pugh, C.W., Schofield, C.J. Chem Sci