CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Short-chain dehydrogenase reductase |
Enzyme Information
| 1.1.1.184 |
Carbonyl reductase (NADPH).
based on mapping to UniProt G5EGA6
R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
-!- Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol. -!- Si-specific with respect to NADPH (cf. EC 1.1.1.2).
|
UniProtKB Entries (1)
| G5EGA6 |
DHRS4_CAEEL
Caenorhabditis elegans
Dehydrogenase/reductase SDR family member 4
|
PDB Structure
| PDB | 5OJI |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure and catalytic characterization of the dehydrogenase/reductase SDR family member 4 (DHRS4) from Caenorhabditis elegans.
FEBS J.
|