CATH Domain 5no1A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.30	SH3 type barrels.
	2.30.30.140

Domain Context

CATH Clusters

Superfamily	2.30.30.140
Functional Family

Enzyme Information

3.1.-.-	Acting on ester bonds. based on mapping to UniProt P14350
3.4.23.-	Aspartic endopeptidases. based on mapping to UniProt P14350
2.7.7.-	Nucleotidyltransferases. based on mapping to UniProt P14350
2.7.7.49	RNA-directed DNA polymerase. based on mapping to UniProt P14350 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
3.1.26.4	Ribonuclease H. based on mapping to UniProt P14350 Endonucleolytic cleavage to 5'-phosphomonoester. -!- Acts on RNA-DNA hybrids.
2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt P14350 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

POL_FOAMV

Human spumaretrovirus

Pro-Pol polyprotein

PDB Structure

PDB	5NO1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors. Zhao, X.Z., Smith, S.J., Maskell, D.P., Metifiot, M., Pye, V.E., Fesen, K., Marchand, C., Pommier, Y., Cherepanov, P., Hughes, S.H., Burke, T.R. J. Med. Chem.