CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
4 | Few Secondary Structures |
|
4.10 | Irregular |
|
4.10.110 | Spasmolytic Protein; domain 1 |
|
4.10.110.10 | Spasmolytic Protein, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Spasmolytic Protein, domain 1 |
| Functional Family | Lysosomal alpha-glucosidase |
Enzyme Information
| 3.2.1.20 |
Alpha-glucosidase.
based on mapping to UniProt P10253
Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
-!- Group of enzymes whose specificity is directed mainly toward the exohydrolysis of 1,4-alpha-glucosidic linkages, and that hydrolyze oligosaccharides rapidly, relative to polysaccharides, which are hydrolyzed relatively slowly, or not at all. -!- The intestinal enzyme also hydrolyzes polysaccharides, catalyzing the reactions of EC 3.2.1.3, and, more slowly, hydrolyzes 1,6-alpha-D- glucose links.
|
UniProtKB Entries (1)
| P10253 |
LYAG_HUMAN
Homo sapiens
Lysosomal alpha-glucosidase
|
PDB Structure
| PDB | 5NN5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of human lysosomal acid alpha-glucosidase-a guide for the treatment of Pompe disease.
Nat Commun
|
