CATH Domain 5ndfF01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.550	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
	3.90.550.10	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

Domain Context

CATH Clusters

Superfamily	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family	Polypeptide N-acetylgalactosaminyltransferase

Enzyme Information

2.4.1.41

Polypeptide N-acetylgalactosaminyltransferase.

based on mapping to UniProt Q10471

(1) UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-serine. (2) UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-threonine.

-!- The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, kappa-casein, apofetuin and some other acceptors of high molecular mass.

UniProtKB Entries (1)

Q10471

GALT2_HUMAN

Homo sapiens

Polypeptide N-acetylgalactosaminyltransferase 2

PDB Structure

PDB	5NDF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The small molecule luteolin inhibits N-acetyl-alpha-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein. Liu, F., Xu, K., Xu, Z., de Las Rivas, M., Wang, C., Li, X., Lu, J., Zhou, Y., Delso, I., Merino, P., Hurtado-Guerrero, R., Zhang, Y., Wu, F. J. Biol. Chem.