1 keywords

CATH Domain 5nakA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.50 3-Layer(bba) Sandwich
Topology 3.50.50 FAD/NAD(P)-binding domain
Homologous Superfamily 3.50.50.60 FAD/NAD(P)-binding domain

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Kynurenine 3-monooxygenase

Enzyme Information

1.14.13.9
Kynurenine 3-monooxygenase.
based on mapping to UniProt Q84HF5
L-kynurenine + NADPH + O(2) = 3-hydroxy-L-kynurenine + NADP(+) + H(2)O.
-!- Formerly EC 1.14.1.2 and EC 1.99.1.5.

UniProtKB Entries (1)

Q84HF5
KMO_PSEFL
Pseudomonas fluorescens
Kynurenine 3-monooxygenase

PDB Structure

PDB 5NAK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.
Hutchinson, J.P., Rowland, P., Taylor, M.R.D., Christodoulou, E.M., Haslam, C., Hobbs, C.I., Holmes, D.S., Homes, P., Liddle, J., Mole, D.J., Uings, I., Walker, A.L., Webster, S.P., Mowat, C.G., Chung, C.W.
Nat Commun