CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Prolyl endopeptidase

Enzyme Information

3.4.21.26
Prolyl oligopeptidase.
based on mapping to UniProt H2E7Q8
Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.
-!- Found in vertebrates, plants and Flavobacterium. -!- Generally cytosolic, commonly activated by thiol compounds. -!- Belongs to peptidase family S9A. -!- Formerly EC 3.4.22.18.

UniProtKB Entries (1)

H2E7Q8
POPB_GALM3
Galerina marginata CBS 339.88
Dual function macrocyclase-peptidase POPB

PDB Structure

PDB 5N4B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates.
Czekster, C.M., Ludewig, H., McMahon, S.A., Naismith, J.H.
Nat Commun