CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.20 | Up-down Bundle | |
1.20.1540 | Rhomboid-like fold | |
1.20.1540.10 | Rhomboid-like |
Domain Context
CATH Clusters
Superfamily | Rhomboid-like |
Functional Family | Rhomboid protease GlpG |
Enzyme Information
3.4.21.105 |
Rhomboid protease.
based on mapping to UniProt P09391
Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.
-!- These endopeptidases are multi-spanning membrane proteins. -!- Their catalytic site is embedded within the membrane and they cleave type-1 transmembrane domains. -!- Important for embryo development in Drosophila melanogaster. -!- Rhomboid is a key regulator of EGF receptor signaling and is responsible for cleaving Spitz, the main ligand of the Drosophila EGF receptor pathway. -!- Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite. -!- Belongs to peptidase family S54.
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UniProtKB Entries (1)
P09391 |
GLPG_ECOLI
Escherichia coli K-12
Rhomboid protease GlpG
|
PDB Structure
PDB | 5MT8 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.
Cell Chem Biol
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