CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.160 |
Domain Context
CATH Clusters
| Superfamily | 1.10.10.160 |
| Functional Family | RecBCD enzyme subunit RecC |
Enzyme Information
| 3.1.11.5 |
Exodeoxyribonuclease V.
based on mapping to UniProt P07648
Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.
-!- Preference for double-stranded DNA. -!- Possesses DNA-dependent ATPase activity. -!- Acts endonucleolytically on single-stranded circular DNA. -!- Similar enzyme: Haemophilus influenzae ATP-dependent DNase.
|
UniProtKB Entries (2)
| P07648 |
RECC_ECOLI
Escherichia coli K-12
RecBCD enzyme subunit RecC
|
| P03702 |
GAM_LAMBD
Escherichia virus Lambda
Host-nuclease inhibitor protein gam
|
PDB Structure
| PDB | 5MBV |
| External Links | |
| Method | ELECTRON MICROSCOPY |
| Organism | |
| Primary Citation |
Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones.
Elife
|
