CATH Domain 5m4nA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.140	Butyryl-CoA Dehydrogenase, subunit A; domain 3
	1.20.140.20	Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain
Functional Family	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

Enzyme Information

2.7.11.2

[Pyruvate dehydrogenase (acetyl-transferring)] kinase.

based on mapping to UniProt Q15119

ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.

-!- Has no activating compound but is specific for its substrate. -!- A mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. -!- Phosphorylation inactivates EC 1.2.4.1. -!- Formerly EC 2.7.1.99.

UniProtKB Entries (1)

Q15119

PDK2_HUMAN

Homo sapiens

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

PDB Structure

PDB	5M4N
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase. Brough, P.A., Baker, L., Bedford, S., Brown, K., Chavda, S., Chell, V., D'Alessandro, J., Davies, N.G., Davis, B., Le Strat, L., Macias, A.T., Maddox, D., Mahon, P.C., Massey, A.J., Matassova, N., McKenna, S., Meissner, J.W., Moore, J.D., Murray, J.B., Northfield, C.J., Parry, C., Parsons, R., Roughley, S.D., Shaw, T., Simmonite, H., Stokes, S., Surgenor, A., Stefaniak, E., Robertson, A., Wang, Y., Webb, P., Whitehead, N., Wood, M. J. Med. Chem.