CATH Domain 5lyoC02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Transmembrane serine protease 7

Enzyme Information

3.4.21.109

Matriptase.

based on mapping to UniProt Q9Y5Y6

Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.

-!- This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis. -!- Can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain form at an Arg residue to give active alpha- and beta-HGF, but it does not activate plasminogen, which shares high homology with HGF. -!- Can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade. -!- Belongs to peptidase family S1A.

UniProtKB Entries (1)

Q9Y5Y6

ST14_HUMAN

Homo sapiens

Suppressor of tumorigenicity 14 protein

PDB Structure

PDB	5LYO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Blocking the proteolytic activity of zymogen matriptase with antibody-based inhibitors. Tamberg, T., Hong, Z., De Schepper, D., Skovbjerg, S., Dupont, D.M., Vitved, L., Schar, C.R., Skjoedt, K., Vogel, L.K., Jensen, J.K. J.Biol.Chem.