CATH Domain 5lsxA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.270	Beta-clip-like
	2.170.270.10	SET domain

Domain Context

CATH Clusters

Superfamily	SET domain
Functional Family	Histone-lysine N-methyltransferase

Enzyme Information

2.1.1.-	Methyltransferases. based on mapping to UniProt Q9BYW2
2.1.1.43	Histone-lysine N-methyltransferase. based on mapping to UniProt Q9BYW2 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

SETD2_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase SETD2

PDB Structure

PDB	5LSX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives. Tisi, D., Chiarparin, E., Tamanini, E., Pathuri, P., Coyle, J.E., Hold, A., Holding, F.P., Amin, N., Martin, A.C., Rich, S.J., Berdini, V., Yon, J., Acklam, P., Burke, R., Drouin, L., Harmer, J.E., Jeganathan, F., van Montfort, R.L., Newbatt, Y., Tortorici, M., Westlake, M., Wood, A., Hoelder, S., Heightman, T.D. ACS Chem. Biol.