CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.12280 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.12280 |
| Functional Family | NADH-quinone oxidoreductase subunit B 2 |
Enzyme Information
| 1.6.99.3 |
NADH dehydrogenase.
based on mapping to UniProt P42026
NADH + acceptor = NAD(+) + reduced acceptor.
-!- After preparations have been subjected to certain treatments cytochrome c may act as acceptor. -!- Under normal conditions, two protons are extruded from the cytoplasm or the intramitochondrial or stromal compartment. -!- Present in a mitochondrial complex as EC 7.1.1.2. -!- Formerly EC 1.6.2.1.
|
| 7.1.1.2 |
NADH:ubiquinone reductase (H(+)-translocating).
based on mapping to UniProt P42026
NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
-!- The complex is present in mitochondria and aerobic bacteria. -!- Breakdown of the complex can release EC 1.6.99.3. -!- In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD(+) to NADH. -!- Formerly EC 1.6.5.3.
|
UniProtKB Entries (2)
| W5NRY1 |
W5NRY1_SHEEP
Ovis aries
Uncharacterized protein
|
| P23934 |
NDUS6_BOVIN
Bos taurus
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
|
PDB Structure
| PDB | 5LNK |
| External Links | |
| Method | ELECTRON MICROSCOPY |
| Organism | |
| Primary Citation |
Atomic structure of the entire mammalian mitochondrial complex I.
Nature
|
