1 keywords

CATH Domain 5liaA02

CATH Classification

Level CATH Code Description
Class 4 Few Secondary Structures
Architecture 4.10 Irregular
Topology 4.10.410 Factor Xa Inhibitor
Homologous Superfamily 4.10.410.20  

Domain Context

CATH Clusters

Superfamily 4.10.410.20
Functional Family Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Enzyme Information

3.1.4.39
Alkylglycerophosphoethanolamine phosphodiesterase.
based on mapping to UniProt Q9R1E6
1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine.
-!- Also acts on acyl and choline analogs.

UniProtKB Entries (1)

Q9R1E6
ENPP2_MOUSE
Mus musculus
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

PDB Structure

PDB 5LIA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of potent inhibitors of the lysophospholipase autotaxin.
Shah, P., Cheasty, A., Foxton, C., Raynham, T., Farooq, M., Gutierrez, I.F., Lejeune, A., Pritchard, M., Turnbull, A., Pang, L., Owen, P., Boyd, S., Stowell, A., Jordan, A., Hamilton, N.M., Hitchin, J.R., Stockley, M., MacDonald, E., Quesada, M.J., Trivier, E., Skeete, J., Ovaa, H., Moolenaar, W.H., Ryder, H.
Bioorg. Med. Chem. Lett.
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