CATH Domain 5l4qA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	AP2 associated kinase 1

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q2M2I8

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q2M2I8

AAK1_HUMAN

Homo sapiens

AP2-associated protein kinase 1

PDB Structure

PDB	5L4Q
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity. Verdonck, S., Pu, S.Y., Sorrell, F.J., Elkins, J.M., Froeyen, M., Gao, L.J., Prugar, L.I., Dorosky, D.E., Brannan, J.M., Barouch-Bentov, R., Knapp, S., Dye, J.M., Herdewijn, P., Einav, S., De Jonghe, S. J.Med.Chem.