CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.30 | Elongation Factor Tu (Ef-tu); domain 3 |
|
2.40.30.110 | Aminomethyltransferase beta-barrel domains |
Domain Context
CATH Clusters
| Superfamily | Aminomethyltransferase beta-barrel domains |
| Functional Family | dimethylglycine dehydrogenase, mitochondrial |
Enzyme Information
| 1.5.8.4 |
Dimethylglycine dehydrogenase.
based on mapping to UniProt Q9UI17
N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein = sarcosine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein.
-!- An imine intermediate is channeled from the FAD binding site to the 5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel. -!- In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms formaldehyde. -!- Formerly EC 1.5.99.2.
|
UniProtKB Entries (1)
| Q9UI17 |
M2GD_HUMAN
Homo sapiens
Dimethylglycine dehydrogenase, mitochondrial
|
PDB Structure
| PDB | 5L46 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant.
Febs J.
|