CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1360 | Gyrase A; domain 2 |
|
3.30.1360.120 | Probable tRNA modification gtpase trme; domain 1 |
Domain Context
CATH Clusters
| Superfamily | Probable tRNA modification gtpase trme; domain 1 |
| Functional Family | dimethylglycine dehydrogenase, mitochondrial |
Enzyme Information
| 1.5.8.4 |
Dimethylglycine dehydrogenase.
based on mapping to UniProt Q9UI17
N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein = sarcosine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein.
-!- An imine intermediate is channeled from the FAD binding site to the 5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel. -!- In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms formaldehyde. -!- Formerly EC 1.5.99.2.
|
UniProtKB Entries (1)
| Q9UI17 |
M2GD_HUMAN
Homo sapiens
Dimethylglycine dehydrogenase, mitochondrial
|
PDB Structure
| PDB | 5L46 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant.
Febs J.
|
