1 keywords

CATH Domain 5l0kA03

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.720 Alkaline Phosphatase, subunit A
Homologous Superfamily 3.40.720.10 Alkaline Phosphatase, subunit A

Domain Context

CATH Clusters

Superfamily Alkaline Phosphatase, subunit A
Functional Family Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Enzyme Information

3.1.4.39
Alkylglycerophosphoethanolamine phosphodiesterase.
based on mapping to UniProt Q64610
1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine.
-!- Also acts on acyl and choline analogs.

UniProtKB Entries (1)

Q64610
ENPP2_RAT
Rattus norvegicus
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

PDB Structure

PDB 5L0K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.
Jones, S.B., Pfeifer, L.A., Bleisch, T.J., Beauchamp, T.J., Durbin, J.D., Klimkowski, V.J., Hughes, N.E., Rito, C.J., Dao, Y., Gruber, J.M., Bui, H., Chambers, M.G., Chandrasekhar, S., Lin, C., McCann, D.J., Mudra, D.R., Oskins, J.L., Swearingen, C.A., Thirunavukkarasu, K., Norman, B.H.
Acs Med.Chem.Lett.