CATH Domain 5krqA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.660	Polyamine Oxidase; Chain A, domain 2
	3.90.660.10

Domain Context

CATH Clusters

Superfamily	3.90.660.10
Functional Family	Renalase

Enzyme Information

1.6.3.5

Renalase.

based on mapping to UniProt Q48MT7

(1) 1,2-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2). (2) 1,6-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2).

-!- Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta- NAD(P)(+). -!- These isomeric forms, generated by nonspecific reduction of beta- NAD(P)(+) or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.

UniProtKB Entries (1)

Q48MT7

RNLS_PSE14

Pseudomonas savastanoi pv. phaseolicola 1448A

Renalase

PDB Structure

PDB	5KRQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Ligand binding phenomena that pertain to the metabolic function of renalase. Beaupre, B.A., Roman, J.V., Hoag, M.R., Meneely, K.M., Silvaggi, N.R., Lamb, A.L., Moran, G.R. Arch.Biochem.Biophys.