CATH Domain 5kbzB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.129	Thiol Ester Dehydrase; Chain A
	3.10.129.110	Polyketide synthase dehydratase

Domain Context

CATH Clusters

Superfamily	Polyketide synthase dehydratase
Functional Family	Sterigmatocystin biosynthesis polyketide synthase

Enzyme Information

2.3.1.221

Noranthrone synthase.

based on mapping to UniProt Q12053

7 malonyl-CoA + hexanoyl-[acyl-carrier protein] = 7 CoA + norsolorinate anthrone + [acyl-carrier protein] + 7 CO(2) + 2 H(2)O.

-!- A multi-domain polyketide synthase involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. -!- The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase.

UniProtKB Entries (1)

Q12053

AFLC_ASPPU

Aspergillus parasiticus SU-1

Norsolorinic acid synthase

PDB Structure

PDB	5KBZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Barajas, J.F., Shakya, G., Moreno, G., Rivera, H., Jackson, D.R., Topper, C.L., Vagstad, A.L., La Clair, J.J., Townsend, C.A., Burkart, M.D., Tsai, S.C. Proc. Natl. Acad. Sci. U.S.A.