CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase

Enzyme Information

1.13.11.80
(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase.
based on mapping to UniProt Q8KLK7
(3,5-dihydroxyphenyl)acetyl-CoA + O(2) = 2-(3,5-dihydroxyphenyl)-2- oxoacetate + CoA.
-!- The enzyme, characterized from bacteria Streptomyces toyocaensis and Amycolatopsis orientalis, is involved in the biosynthesis of (3,5- dihydroxyphenyl)glycine, a component of the glycopeptide antibiotic vancomycin.

UniProtKB Entries (1)

Q8KLK7
DPGC_STRTO
Streptomyces toyocaensis
(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase

PDB Structure

PDB 5KAJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Probing the structural basis of oxygen binding in a cofactor-independent dioxygenase.
Li, K., Fielding, E.N., Condurso, H.L., Bruner, S.D.
Acta Crystallogr D Struct Biol