CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1740 | Rna Polymerase Sigma Factor; Chain: A |
|
1.10.1740.10 | RNA polymerase sigma factor, region 2, helix turn helix motif |
Domain Context
CATH Clusters
| Superfamily | 1.10.1740.10 |
| Functional Family | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic |
Enzyme Information
| 1.1.1.267 |
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
based on mapping to UniProt Q8IKG4
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.
|
UniProtKB Entries (1)
| Q8IKG4 |
DXR_PLAF7
Plasmodium falciparum 3D7
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic
|
PDB Structure
| PDB | 5JO0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.
Chemmedchem
|
