CATH Domain 5jmvA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.40	ATPase, nucleotide binding domain

Domain Context

CATH Clusters

Superfamily	3.30.420.40
Functional Family	Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein

Enzyme Information

2.3.1.234

N(6)-L-threonylcarbamoyladenine synthase.

based on mapping to UniProt Q58530

L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L- threonylcarbamoyladenine(37) in tRNA.

-!- The enzyme is involved in the synthesis of N(6)- threonylcarbamoyladenosine(37) in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNA(Ile), tRNA(Thr), tRNA(Asn), tRNA(Lys), tRNA(Ser) and tRNA(Arg). -!- Formerly EC 2.6.99.4.

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q58530

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (2)

Q8TZI1	Q8TZI1_PYRFU Pyrococcus furiosus DSM 3638 Uncharacterized protein
Q58530	KAE1B_METJA Methanocaldococcus jannaschii DSM 2661 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein

PDB Structure

PDB	5JMV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis. Wan, L.C., Pillon, M.C., Thevakumaran, N., Sun, Y., Chakrabartty, A., Guarne, A., Kurinov, I., Durocher, D., Sicheri, F. Nucleic Acids Res.