CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.50 | Rossmann fold |
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3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
Superfamily | NAD(P)-binding Rossmann-like Domain |
Functional Family | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
Enzyme Information
1.1.1.267 |
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
based on mapping to UniProt Q8IKG4
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.
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UniProtKB Entries (1)
Q8IKG4 |
DXR_PLAF7
Plasmodium falciparum 3D7
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic
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PDB Structure
PDB | 5JMP |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.
Chemmedchem
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