CATH Domain 5jljB00

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.29	PH-domain like
	2.30.29.30	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Superfamily	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family	Ran-specific GTPase-activating protein 1

P62826	RAN_HUMAN Homo sapiens GTP-binding nuclear protein Ran
P41920	YRB1_YEAST Saccharomyces cerevisiae S288C Ran-specific GTPase-activating protein 1

PDB	5JLJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Hing, Z.A., Fung, H.Y., Ranganathan, P., Mitchell, S., El-Gamal, D., Woyach, J.A., Williams, K., Goettl, V.M., Smith, J., Yu, X., Meng, X., Sun, Q., Cagatay, T., Lehman, A.M., Lucas, D.M., Baloglu, E., Shacham, S., Kauffman, M.G., Byrd, J.C., Chook, Y.M., Garzon, R., Lapalombella, R. Leukemia