CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family Cytochrome P450 aromatase

Enzyme Information

1.14.14.14
Aromatase.
based on mapping to UniProt P11511
(1) Testosterone + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = 17-beta-estradiol + formate + 4 H(2)O + 3 [oxidized NADPH--hemoprotein reductase]. (2) Androst-4-ene-3,17-dione + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = estrone + formate + 4 H(2)O + 3 [oxidized NADPH--hemoprotein reductase].
-!- The enzyme catalyzes three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17-beta- estradiol, respectively.

UniProtKB Entries (1)

P11511
CP19A_HUMAN
Homo sapiens
Aromatase

PDB Structure

PDB 5JL9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Testosterone complex and non-steroidal ligands of human aromatase.
Ghosh, D., Egbuta, C., Lo, J.
J. Steroid Biochem. Mol. Biol.