CATH Classification

Domain Context

CATH Clusters

Superfamily Uracil-DNA glycosylase-like domain
Functional Family Uracil-DNA glycosylase

Enzyme Information

3.2.2.27
Uracil-DNA glycosylase.
based on mapping to UniProt P13051
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
-!- Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. -!- Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolyzing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalyzing the removal of mis-incorporated uracil from DNA.

UniProtKB Entries (2)

P12520
VPR_HV1N5
Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)
Protein Vpr
Q9Y4B6
DCAF1_HUMAN
Homo sapiens
DDB1- and CUL4-associated factor 1

PDB Structure

PDB 5JK7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction.
Wu, Y., Zhou, X., Barnes, C.O., DeLucia, M., Cohen, A.E., Gronenborn, A.M., Ahn, J., Calero, G.
Nat.Struct.Mol.Biol.