CATH Classification
Level | CATH Code | Description |
---|---|---|
![]() |
1 | Mainly Alpha |
![]() |
1.10 | Orthogonal Bundle |
![]() |
1.10.800 | Phenylalanine Hydroxylase |
![]() |
1.10.800.10 | Aromatic amino acid hydroxylase |
Domain Context
CATH Clusters
Superfamily | Aromatic amino acid hydroxylase |
Functional Family | tryptophan 5-hydroxylase 1 |
Enzyme Information
1.14.16.4 |
Tryptophan 5-monooxygenase.
based on mapping to UniProt P17752
L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.
-!- Activated by phosphorylation, catalyzed by a Ca(2+)-activated protein kinase. -!- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96. -!- The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.
|
UniProtKB Entries (1)
P17752 |
TPH1_HUMAN
Homo sapiens
Tryptophan 5-hydroxylase 1
|
PDB Structure
PDB | 5J6D |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors.
Bioorg.Med.Chem.Lett.
|