CATH Domain 5j6aA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.140	Butyryl-CoA Dehydrogenase, subunit A; domain 3
	1.20.140.20	Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain
Functional Family	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

Enzyme Information

2.7.11.2

[Pyruvate dehydrogenase (acetyl-transferring)] kinase.

based on mapping to UniProt Q15119

ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.

-!- Has no activating compound but is specific for its substrate. -!- A mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. -!- Phosphorylation inactivates EC 1.2.4.1. -!- Formerly EC 2.7.1.99.

UniProtKB Entries (1)

Q15119

PDK2_HUMAN

Homo sapiens

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

PDB Structure

PDB	5J6A
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors. Tso, S.C., Lou, M., Wu, C.Y., Gui, W.J., Chuang, J.L., Morlock, L.K., Williams, N.S., Wynn, R.M., Qi, X., Chuang, D.T. J. Med. Chem.