CATH Domain 5ix0A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.800	Arginase; Chain A
	3.40.800.20	Histone deacetylase domain

Domain Context

CATH Clusters

Superfamily	Histone deacetylase domain
Functional Family	Histone deacetylase

Enzyme Information

3.5.1.98

Histone deacetylase.

based on mapping to UniProt Q92769

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

-!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone. -!- The reaction of this enzyme is opposite to that of EC 2.3.1.48. -!- Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization. -!- Histone acetylation plays an important role in regulation of gene expression. -!- In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. -!- May be identical to EC 3.5.1.17.

UniProtKB Entries (1)

Q92769

HDAC2_HUMAN

Homo sapiens

Histone deacetylase 2

PDB Structure

PDB	5IX0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Wagner, F.F., Weiwer, M., Steinbacher, S., Schomburg, A., Reinemer, P., Gale, J.P., Campbell, A.J., Fisher, S.L., Zhao, W.N., Reis, S.A., Hennig, K.M., Thomas, M., Muller, P., Jefson, M.R., Fass, D.M., Haggarty, S.J., Zhang, Y.L., Holson, E.B. Bioorg.Med.Chem.