CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1100 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.1100 |
| Functional Family | Cysteine synthase |
Enzyme Information
| 2.5.1.113 |
[CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase.
based on mapping to UniProt P9WP53
O-phospho-L-serine + [CysO sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH = [CysO sulfur-carrier protein]-Gly-NH-CH(2)-C(O)-S-L-cysteine + phosphate.
-!- The enzyme participates in an alternative pathway for L-cysteine biosynthesis that involves a protein-bound thiocarboxylate as the sulfide donor. -!- The enzyme from the bacterium Mycobacterium tuberculosis also has very low activity with O(3)-acetyl-L-serine (cf. EC 2.5.1.65). -!- Formerly EC 2.5.1.n5.
|
UniProtKB Entries (1)
| P9WP53 |
CYSM_MYCTU
Mycobacterium tuberculosis H37Rv
O-phosphoserine sulfhydrylase
|
PDB Structure
| PDB | 5IWC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
J.Med.Chem.
|
