CATH Domain 5iozA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.357	Tetracycline Repressor; domain 2
	1.10.357.10	Tetracycline Repressor, domain 2

Domain Context

CATH Clusters

Superfamily	Tetracycline Repressor, domain 2
Functional Family	HTH-type transcriptional regulator EthR

Enzyme Information

UniProtKB Entries (1)

A5U9I4_MYCTA

Mycobacterium tuberculosis H37Ra

TetR-family transcriptional regulatory repressor protein

PDB Structure

PDB	5IOZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. Nikiforov, P.O., Blaszczyk, M., Surade, S., Boshoff, H.I., Sajid, A., Delorme, V., Deboosere, N., Brodin, P., Baulard, A.R., Barry, C.E., Blundell, T.L., Abell, C. ACS Chem. Biol.