CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.25 | UDP-galactose 4-epimerase; domain 1 |
|
3.90.25.10 | UDP-galactose 4-epimerase, domain 1 |
Domain Context
CATH Clusters
| Superfamily | UDP-galactose 4-epimerase, domain 1 |
| Functional Family |
Enzyme Information
| 4.2.1.47 |
GDP-mannose 4,6-dehydratase.
based on mapping to UniProt O60547
GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H(2)O.
-!- Forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-alpha-L-fucose. -!- In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalyzing the above reaction as well as the reaction catalyzed by EC 1.1.1.281.
|
UniProtKB Entries (1)
| O60547 |
GMDS_HUMAN
Homo sapiens
GDP-mannose 4,6 dehydratase
|
PDB Structure
| PDB | 5IN5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase.
Acs Chem.Biol.
|