CATH Domain 5i60B02

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.10	D-amino Acid Aminotransferase; Chain A, domain 2
	3.20.10.10	D-amino Acid Aminotransferase, subunit A, domain 2

Superfamily	D-amino Acid Aminotransferase, subunit A, domain 2
Functional Family	Branched-chain-amino-acid aminotransferase, mitochondrial

2.6.1.42

Branched-chain-amino-acid transaminase.

based on mapping to UniProt O15382

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.

-!- Also acts on L-isoleucine and L-valine. -!- Different from EC 2.6.1.66.

BCAT2_HUMAN

Homo sapiens

Branched-chain-amino-acid aminotransferase, mitochondrial

PDB	5I60
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening. Borthwick, J.A., Ancellin, N., Bertrand, S.M., Bingham, R.P., Carter, P.S., Chung, C.W., Churcher, I., Dodic, N., Fournier, C., Francis, P.L., Hobbs, A., Jamieson, C., Pickett, S.D., Smith, S.E., Somers, D.O., Spitzfaden, C., Suckling, C.J., Young, R.J. J.Med.Chem.