CATH Domain 5i2kA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.190	D-Maltodextrin-Binding Protein; domain 2
	3.40.190.10	Periplasmic binding protein-like II

Domain Context

CATH Clusters

Superfamily	Periplasmic binding protein-like II
Functional Family	Putative glutamate receptor ionotropic NMDA 2B

Enzyme Information

UniProtKB Entries (1)

NMDZ1_HUMAN

Homo sapiens

Glutamate receptor ionotropic, NMDA 1

PDB Structure

PDB	5I2K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design. Volgraf, M., Sellers, B.D., Jiang, Y., Wu, G., Ly, C.Q., Villemure, E., Pastor, R.M., Yuen, P.W., Lu, A., Luo, X., Liu, M., Zhang, S., Sun, L., Fu, Y., Lupardus, P.J., Wallweber, H.J., Liederer, B.M., Deshmukh, G., Plise, E., Tay, S., Reynen, P., Herrington, J., Gustafson, A., Liu, Y., Dirksen, A., Dietz, M.G., Liu, Y., Wang, T.M., Hanson, J.E., Hackos, D., Scearce-Levie, K., Schwarz, J.B. J.Med.Chem.