CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1010 | Cobalt-precorrin-4 Transmethylase; domain 1 |
|
3.40.1010.10 | Cobalt-precorrin-4 Transmethylase; Domain 1 |
Domain Context
CATH Clusters
| Superfamily | Cobalt-precorrin-4 Transmethylase; Domain 1 |
| Functional Family | Ribosomal RNA small subunit methyltransferase I |
Enzyme Information
| 2.1.1.198 |
16S rRNA (cytidine(1402)-2'-O)-methyltransferase.
based on mapping to UniProt P67087
S-adenosyl-L-methionine + cytidine(1402) in 16S rRNA = S-adenosyl-L- homocysteine + 2'-O-methylcytidine(1402) in 16S rRNA.
-!- RsmI catalyzes the 2'-O-methylation of cytidine(1402) and RsmH (EC 2.1.1.199) catalyzes the N(4)-methylation of cytidine(1402) in 16S rRNA. -!- Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.
|
UniProtKB Entries (1)
| P67087 |
RSMI_ECOLI
Escherichia coli K-12
Ribosomal RNA small subunit methyltransferase I
|
PDB Structure
| PDB | 5HW4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Insights into the Methylation of C1402 in 16S rRNA by Methyltransferase RsmI
Plos One
|