CATH Domain 5hvyA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	cyclin-dependent kinase 8 isoform X1

Enzyme Information

2.7.11.23

[RNA-polymerase]-subunit kinase.

based on mapping to UniProt P49336

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

-!- Appears to be distinct from other protein phosphokinases. -!- Brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6. -!- Does not phosphorylate casein, phosvitin or histone. -!- Formerly EC 2.7.1.141.

2.7.11.22

Cyclin-dependent kinase.

based on mapping to UniProt P49336

ATP + a protein = ADP + a phosphoprotein.

-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P49336

CDK8_HUMAN

Homo sapiens

Cyclin-dependent kinase 8

PDB Structure

PDB	5HVY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8. Bergeron, P., Koehler, M.F., Blackwood, E.M., Bowman, K., Clark, K., Firestein, R., Kiefer, J.R., Maskos, K., McCleland, M.L., Orren, L., Ramaswamy, S., Salphati, L., Schmidt, S., Schneider, E.V., Wu, J., Beresini, M. Acs Med.Chem.Lett.