CATH Domain 5hp4A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.150	DNA polymerase; domain 1
	1.10.150.20	5' to 3' exonuclease, C-terminal subdomain

Domain Context

CATH Clusters

Superfamily	5' to 3' exonuclease, C-terminal subdomain
Functional Family	T5 flap endonuclease

Enzyme Information

3.1.11.3	Exodeoxyribonuclease (lambda-induced). based on mapping to UniProt P06229 Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates. -!- Preference for double-stranded DNA. -!- Does not attack single-strand breaks. -!- Similar enzymes: T4, T5 and T7 exonucleases, mammalian DNase IV. -!- Formerly EC 3.1.4.28.
3.1.11.-	Exodeoxyribonucleases producing 5'-phosphomonoesters. based on mapping to UniProt P06229

UniProtKB Entries (1)

EXO5_BPT5

Escherichia virus T5

T5 flap endonuclease

PDB Structure

PDB	5HP4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Direct observation of DNA threading in flap endonuclease complexes. AlMalki, F.A., Flemming, C.S., Zhang, J., Feng, M., Sedelnikova, S.E., Ceska, T., Rafferty, J.B., Sayers, J.R., Artymiuk, P.J. Nat.Struct.Mol.Biol.