CATH Domain 5hneA01

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.470	D-amino Acid Aminotransferase; Chain A, domain 1
	3.30.470.10	Aminotransferase class 4, branched-chain amino acid transferase, N-terminal domain

Superfamily	3.30.470.10
Functional Family	Branched-chain-amino-acid aminotransferase

2.6.1.42

Branched-chain-amino-acid transaminase.

based on mapping to UniProt O15382

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.

-!- Also acts on L-isoleucine and L-valine. -!- Different from EC 2.6.1.66.

BCAT2_HUMAN

Homo sapiens

Branched-chain-amino-acid aminotransferase, mitochondrial

PDB	5HNE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors. Deng, H., Zhou, J., Sundersingh, F., Messer, J.A., Somers, D.O., Ajakane, M., Arico-Muendel, C.C., Beljean, A., Belyanskaya, S.L., Bingham, R., Blazensky, E., Boullay, A.B., Boursier, E., Chai, J., Carter, P., Chung, C.W., Daugan, A., Ding, Y., Herry, K., Hobbs, C., Humphries, E., Kollmann, C., Nguyen, V.L., Nicodeme, E., Smith, S.E., Dodic, N., Ancellin, N. Acs Med.Chem.Lett.