CATH Domain 5hggA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Urokinase-type plasminogen activator

Enzyme Information

3.4.21.73

U-plasminogen activator.

based on mapping to UniProt P00749

Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.

-!- Formed from the inactive precursor by action of plasmin or plasma kallikrein. -!- Differs in structure from EC 3.4.21.68, and does not bind to fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P00749

UROK_HUMAN

Homo sapiens

Urokinase-type plasminogen activator

PDB Structure

PDB	5HGG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior Kromann-Hansen, T., Oldenburg, E., Yung, K.W., Ghassabeh, G.H., Muyldermans, S., Declerck, P.J., Huang, M., Andreasen, P.A., Ngo, J.C. J.Biol.Chem.