CATH Domain 5hexA02

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.40	ATPase, nucleotide binding domain

Superfamily	3.30.420.40
Functional Family	Hexokinase-2

2.7.1.1

Hexokinase.

based on mapping to UniProt P52789

ATP + D-hexose = ADP + D-hexose 6-phosphate.

-!- D-glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors. -!- ITP and dATP can act as donors.

HXK2_HUMAN

Homo sapiens

Hexokinase-2

PDB	5HEX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors. Lin, H., Zeng, J., Xie, R., Schulz, M.J., Tedesco, R., Qu, J., Erhard, K.F., Mack, J.F., Raha, K., Rendina, A.R., Szewczuk, L.M., Kratz, P.M., Jurewicz, A.J., Cecconie, T., Martens, S., McDevitt, P.J., Martin, J.D., Chen, S.B., Jiang, Y., Nickels, L., Schwartz, B.J., Smallwood, A., Zhao, B., Campobasso, N., Qian, Y., Briand, J., Rominger, C.M., Oleykowski, C., Hardwicke, M.A., Luengo, J.I. Acs Med.Chem.Lett.