CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.20 | Up-down Bundle |
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1.20.1220 | Malate Synthase G; Chain: A; Domain 4 |
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1.20.1220.12 | Malate synthase, domain III |
Domain Context
CATH Clusters
Superfamily | Malate synthase, domain III |
Functional Family |
Enzyme Information
2.3.3.9 |
Malate synthase.
based on mapping to UniProt P9WK17
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.
-!- The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. -!- Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2). -!- Formerly EC 4.1.3.2.
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UniProtKB Entries (1)
P9WK17 |
MASZ_MYCTU
Mycobacterium tuberculosis H37Rv
Malate synthase G
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PDB Structure
PDB | 5H8U |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem.
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