CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.10 | Orthogonal Bundle |
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1.10.510 | Transferase(Phosphotransferase); domain 1 |
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1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
Superfamily | Transferase(Phosphotransferase) domain 1 |
Functional Family | Protein O-mannose kinase |
Enzyme Information
2.7.1.183 |
Glycoprotein-mannosyl O(6)-kinase.
based on mapping to UniProt Q5U3W1
ATP + O(3)-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D- glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl/L-seryl-[protein] = ADP + O(3)-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D- glucosaminyl-(1->4)-alpha-D-(6-phospho)mannosyl)-L-threonyl/L-seryl- [protein].
-!- In humans this phosphorylated trisaccharide is attached to an L-threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and is important for its activity.
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UniProtKB Entries (1)
Q5U3W1 |
SG196_DANRE
Danio rerio
Protein O-mannose kinase
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PDB Structure
PDB | 5GZA |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure of protein O-mannose kinase reveals a unique active site architecture
Elife
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