CATH Classification

Domain Context

CATH Clusters

Superfamily Topoisomerase, domain 3
Functional Family DNA topoisomerase 2

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P11388
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P11388
TOP2A_HUMAN
Homo sapiens
DNA topoisomerase 2-alpha

PDB Structure

PDB 5GWK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Wang, Y.R., Chen, S.F., Wu, C.C., Liao, Y.W., Lin, T.S., Liu, K.T., Chen, Y.S., Li, T.K., Chien, T.C., Chan, N.L.
Nucleic Acids Res.