1 keywords

CATH Domain 5guvA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.150 Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family DNA (cytosine-5)-methyltransferase

Enzyme Information

2.1.1.37
DNA (cytosine-5-)-methyltransferase.
based on mapping to UniProt P13864
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
-!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/ -!- Formerly EC 2.1.1.73.

UniProtKB Entries (1)

P13864
DNMT1_MOUSE
Mus musculus
DNA (cytosine-5)-methyltransferase 1

PDB Structure

PDB 5GUV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.
Ye, F., Kong, X.Q., Zhang, H., Liu, Y., Shao, Z., Jin, J., Cai, Y., Zhang, R., Li, L., Zhang, Y.W., Liu, Y.C., Zhang, C., Xie, W., Yu, K., Ding, H., Zhao, K., Chen, S., Jiang, H., Baylin, S.B., Luo, C.
ACS Chem. Biol.