CATH Domain 5g0tA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Enoyl-[acyl-carrier-protein] reductase [NADH]

Enzyme Information

1.3.1.9

Enoyl-[acyl-carrier-protein] reductase (NADH).

based on mapping to UniProt P9WGR1

An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH.

-!- The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety. -!- The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18. -!- The FAS-I enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.

UniProtKB Entries (1)

P9WGR1

INHA_MYCTU

Mycobacterium tuberculosis H37Rv

Enoyl-[acyl-carrier-protein] reductase [NADH]

PDB Structure

PDB	5G0T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Cofactor-Specific, Bactericidal Mycobacterium Tuberculosis Inha Inhibitors Using DNA-Encoded Library Technology Soutter, H.H., Centrella, P., Clark, M.A., Cuozzo, J.W., Dumelin, C.E., Guie, M.-A., Habeshian, S., Keefe, A.D., Kennedy, K.M., Sigel, E.A., Troast, D.M., Zhang, Y., Ferguson, A.D., Davies, G., Stead, E.R., Breed, J., Madhavapeddi, P., Read, J.A. Proc.Natl.Acad.Sci.USA